Clinical application of recombinant human bone morphogenetic protein in cats and dogs: a review of 13 cases.
Database (2001-2008) for cases in which the recombinant bone morphogenetic protein (rhBMP) is used to assist in the management of orthopedic diseases are reviewed and categorized as cases of non-union, delayed union, and the case is expected to Swine Recombinant Proteins heal with difficulty. If follow-up in the medical record is <6 mo for live animals, the owners were surveyed by telephone. Thirteen cases (11 dogs, 2 cats) were identified; OP-1 (rhBMP-7) was used in 3 cases and infusions (rhBMP-2) in 10. Mean time from injury to the use of rhBMP for cases of non and delayed union is 156 d; Average time of rhBMP used for radiographic healing was 101 d. No systemic side effects were reported. All patients achieved clinical and radiographic bone union after administration of rhBMP. Human recombinant BMP is used in 13 patients of animals to successfully achieve bony union without seriously damaging effects in a variety of clinical applications. cluster core-shell prot...